Ayellet V. Segrè, Ph.D.
Assistant Professor of Ophthalmology, Harvard Medical School
Genetic Biostatistician, Ocular Genomics Institute, Massachussetts Eye and Ear
Associate Member, Broad Institute of Harvard and MIT
Member of the Genotype-Tissue Expression (GTEx) Project Consortium
E-mail: ayellet_segre [at] meei.harvard.edu
Andrew Hamel, Computational Biologist
M.Sc. in Bioinformatics Program at Boston University
B.A. in Biochemistry and Molecular Biology; Minor in Mathematics, The College of Wooster, Wooster, Ohio
E-mail: andrew_hamel [at] meei.harvard.edu
Andrew is interested in combining functional genomics and systems biology with genome-wide association studies of complex diseases to gain new biological insights on the causes of disease. He is currently working on developing GWAS-eQTL enrichment methods to identify regulatory mechanisms, genes, and tissues that are implicated by genetic associations with complex eye diseases.
John Rouhana, Computational Biologist
M.Sc. in Bioinformatics, Northeastern University, Boston, MA
B.Sc. in Premedical and Health Studies, MCPHS University, Boston, MA
E-mail: John_Rouhana [at] meei.harvard.edu
John is developing methods that integrate expression and splicing QTLs and pathway information with GWAS data to shed light on the causal mechanisms and genes of complex diseases, with a focus on common eye diseases. He is also working on discovering genetic effects on splicing in the retina, to further characterize the retina transcriptome and uncover genetic regulation associated with retinal degeneration diseases.