Principal Investigator

Ayellet V. Segrè, Ph.D.
Assistant Professor of Ophthalmology, Harvard Medical School
Co-Director, Biostatistics and Bioinformatics, Ocular Genomics Institute, Massachussetts Eye and Ear
Associate Member, Broad Institute of Harvard and MIT
Member of the Genotype-Tissue Expression (GTEx) Project Consortium

E-mail: ayellet_segre [at]


Lab Members

Andrew Hamel, Computational Biologist
M.Sc. in Bioinformatics Program at Boston University

B.A. in Biochemistry and Molecular Biology; Minor in Mathematics, The College of Wooster, Wooster, Ohio

E-mail: andrew_hamel [at]

Andrew is interested in combining functional genomics and systems biology with genome-wide association studies of complex diseases to gain new biological insights on the causes of disease. He is currently working on developing GWAS-eQTL enrichment methods to identify regulatory mechanisms, genes, and tissues that are implicated by genetic associations with complex eye diseases.

John Rouhana, Computational Biologist

M.Sc. in Bioinformatics, Northeastern University, Boston, MA

B.Sc. in Premedical and Health Studies, MCPHS University, Boston, MA

E-mail: John_Rouhana [at]

John is computational developing methods that integrate expression and splicing QTLs and pathway information with GWAS data to shed light on the causal mechanisms and genes of complex diseases, with a focus on common eye diseases. He is also working on discovering genetic effects on splicing in the retina, to further characterize the retina transcriptome and uncover genetic regulation associated with retinal degeneration diseases.

Jacqueline Ohmura, MD student in Harvard and MIT Health, Sciences and Technology (HST) MD program

Ph.D. in Biological Engineering, MIT

B.S. Materials Engineering, Ohio State University, Columbus, OH

E-mail: Ohmura [at]

Co-mentored with Prof. Janey Wiggs, Mass. Eye and Ear, HMS

We are looking for graduate students and post-docs interested in statistical genetics and functional genomics of complex eye diseases to join our team!  More details can be found here